The key success factors for Nike Essay Essay Example

The key success factors for Nike? Essay Essay Nike. originally known as Blue Ribbon Spots is involved in the design. development and world-wide selling of footwear. dress. equipment and accoutrement merchandises which started its journey in early 1962. In about 200 states with around 18. 000 retail histories Nike is now the largest marketer of athletic footwear in the universe. The company focused on presenting high quality running places designed particularly for jocks by jocks. Behind its success. among many factors two cardinal factors can be easy seen which are Advertising and Marketing. Nike placed a important weight on selling and publicizing the company and its merchandises. Nike strongly bonded the contracts with extremely successful and influential jocks. managers. squads like Michael Jordan. Serena Williams. and Tiger Woods to popularise its places and other athleticss accoutrements. In its advertisement runs. Professional jocks were used which was proved both effectual and efficient. Nike besides actively followed and applied some selling programs and plans to prolong its laterality in the industry and remain competitory. Like Nike Responded to tendencies and alterations in consumer penchant by seting the mix of bing merchandise offerings. developing new merchandises. manners and classs. and influencing athleticss and fittingness penchants through its aggressive selling. Nike marketed and advertised its merchandises chiefly through Television. magazines. and runs which besides were effectual and efficient. We will write a custom essay sample on The key success factors for Nike? Essay specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on The key success factors for Nike? Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on The key success factors for Nike? Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Where is Nike vulnerable? What should they watch out for? There is a fact ; Nike was asserted in utilizing famous person indorsements in their advertizers and runs. But they need to maintain in head that they should non allow the famous persons become their trade name image. If it was so. the company would run the hazard of decreasing the trade name every bit shortly as famous person becomes faded. But in the early age. they did non believe about the job that might lift by registration of single jocks ; because at a clip. people dies andnew people come in. So in such a instance ; if a famous person is Nike’s trade name image it will be lost every bit shortly as the famous person is no more. or in this instance the trade name has fallen. Nike can watch out the undermentioned things to watch out for their trade name: 1. Choosing a interpreter whose features are similar every bit good as congruent with their trade name image. 2. Nike trades with lone one merchandise line ; which is footwear. In this circumstance. Nike should watch out for merchandise variegation in order to increase their portion in the U. S market every bit good as the planetary market What recommendations would you do to their senior selling executives traveling frontward? Anyone’s short list of the world’s taking trade names would certainly include Nike. the planetary icon for the athletic places. The Nike trade name has become so strong. Brand direction is one of Nike’s many strengths. Consumers are willing to pay more for trade names that they judge to be superior in quality. manner and dependability and Nike has acquired the stigmatization image with its engineering based production methods and alone selling scheme. It is thought that utilizing professional jocks in advertisement run is both effectual and efficient. But today. athletic places market is really much competitory. Numbers of rivals are increasing twenty-four hours by twenty-four hours. They are besides seeking to take the portion of the net income by making trade name image in the consumers mind. As Nike has already created the trade name image to the consumers mind. selling directors ever need to be watchful to do certain to stable the trade name image. Nike reduced its production cost by importing places from abroad. But marketing executives should maintain in head that quality affairs. If cut downing cost reduces quality. sellers should non travel after it. Because quality cavities trade name image and that’s why quality should ever be increased to vie with the rivals. Nike is fabricating athletic places. If it tries to convert consumers to alter the usage form of these places. like they may utilize those places casually or at place. sells may increase. They should diversify the form of places. Nike can besides come in into other market relates to the footwear market to diversify its market portion. They are aiming merely the immature people clients. But a big metameric group of old and child group is non targeted. Nike can do footwear for the old and kid besides. For capturing local markets. Nike needs to plan and fabricate footwear for the local athleticss. Though Nike is fabricating athletic places for approximately more or less 30 athleticss. but there are many other local athleticss in different states. If Nike does this. it can besides get the better of local trade names and can besides increase its abroad grosss more. What should they be certain to make with its selling? 1. Nike should be certain supplying the nucleus values of the trade name what is the base construct of the trade name. Organization should utilize it as their singularity of their merchandise quality. characteristic and. after the full trade name image. 2. They should be cared of the selling run of the interpreter as if there are no anything unrealistic attitude high spots for which the people’s perceptual experience can be converted negatively. Spokes individual map should be influence able to all types of people. 3. For presenting their merchandise in the foreign market. they have to see the local market. their civilization and faith for the selling advertisement. run. Some state has traditional norms of civilization A ; strong believes in faith. 4. In footings of making a highly-flavored psychological value in the consumer head. they should guarantee come offing in assisting the many current catastrophes. Particularly. the recent issue â€Å"Anti-Global worming† plan obviously can do a better idea about the corporation. 5. In the Asia. Nike is non still that much popular as it is in the America A ; Europe so for ruling the Asiatic states and do its root in the deep of the market it has to be certain the maestro selling program. Although Nike is the market dominator in the athletic footwear market. it should be certain it’s strategic selling program for spread outing its field towards more headlong and conspicuously.

SQL BUSINESS REPORT essays

SQL BUSINESS REPORT essays Third-Part Augmenting Software and Enhancements 5 Data modification and retrieval 9 Application Environment 10 The Team A Corporation is the creator of a next-generation software program called Do It All Software. Team A is planning to soon start a user Beta testing program for Do It All Software. The Team A beta test management team is expecting a heavy interest by users to test the program and is preparing a website to assist them. Team A anticipates that the website will be updated several times a day. Team A plans to create a SQL driven Content Management System for the current website that will allow the beta test team members to dynamically update pages on the website and create new pages as needed, without worrying about knowing HTML. The Content management System (CMS) will be primarily used to manage a beta-testing website for the new software programs. The Team A beta test management team will be creating pages to support the development and beta test of Do It All Software. The main goal is to make it easy for the beta test management team to create, manage, distribution, and publish pages to the website. It will also have the ability to manage the structure of the site, the appearance of the published pages, and basic site navigation provided to the users. Since Team A anticipates a high number of beta testers, powerful hardware and software will need to be utilized. To meet these requirements, the CMS will run on multi-processor Intel based server running Microsoft Windows 2003 Server. The CMS will be developed by in-house engineers using Microsoft SQL Server as the database engine to manage and store beta testing information on Microsoft Internet Information Server (IIS) and ASP.NET to serve the website pages. The initial CMS prototype will be developed using Microsoft Access because of it ease of use. The CMS will require beta testers to register on the website. The foll...

Case Study on Profitability Assignment Example | Topics and Well Written Essays - 1500 words

Case Study on Profitability - Assignment Example Thus the decrease in operating profit margin indicates that operating expenses of Deutsche Brauerei rise faster than its sales, which can be clearly seen from exhibit 1: 48.4% increase in sales against 49.5% increase in operating expenses. In turn this means Deutsche Brauerei now has less flexibility in determining prices, and therefore less safety in tough economic times. The ratio of income taxes to earnings before taxes has also increased to 39.5% in 1999 and 39% in 2000 from 33.8% in 1997 and 34.5% in 1998. From exhibit 1 we can see that taxable income increase steadily over years (which can be explained by unstable economic situation in Ukraine), while earnings before taxes grow slower. Consequently return on sales, which shows the operational efficiency of the company dividing earnings before tax by total sales, has decreased from 4% in 1998 (before default) to 2.8% in 1999 leveling the breakdown to 3.2% in 2000. Still shareholders' equity continues to increase shifting the return on equity ratio up to 10.3% in 2000 - the highest measure for four years; the business looks good from this perspective. Return on net assets which is equal to net income divided by fixed assets and net working capital also shows signs of healthy performance increasing to 8.4% in 2000 6.9% in previous year. The return on assets ratio have returned to its value in 1998 - 4.7% - indicating that a company puts its assets to good use when restoring profitability after economic breakdown in former USSR region. As can be seen from the exhibit 1, sales in Germany have been increasing slowly over the last four years, while the main stake was made on the Ukrainian market. Therefore changes in profitability of DB are greatly affected by local economic climate, which was very unstable these years. Although experiencing difficulties in generating profit, DB has made a successful recover from economic difficulties of the year 1998. Leverage Leverage ratios determine the company's long-term solvency. "Financial leverage is the name given to the impact on returns of a change in the extent to which the firm's assets are financed with borrowed money." (Scott, 1998) For instance debt/equity ratio shows how much money the company can safely borrow over long-terms and it is measured with dividing the total debt with total equity. The debt/equity ratio for DB has fallen from 72.3% in 1997 to 66% in 2000. The company has borrowed funds in 1997 making investments into Ukrainian market, which is the reason of such high debt/equity ratio in 1997. It is decreasing along with debt/total capital ratio (long-term debt/ long term-debt + shareholder's equity), which was 39.8% in 2000 comparing to 41.9% in 1997. This is a good sign of increasing long-term solvency. EBIT/interest ratio, which shows how many times the company can cover its obligations was rather stable during the last three years (4.7 in 1999, 2000, 4.8 in 1998) increasing significantly from 3.8 in 1997. The company has significantly decreased its debt in 1998, which was reflected in the increased solvency in the last three years. Asset Utilization The efficiency of the business is measured by asset usage ratios. Asset utilization ratios are especially important for internal monitoring concerning performance over multiple periods, serving as warning signals or benchmarks from which meaningful conclusions may be reached on operational issues (Blok and Hirt, 2005). Asset turnover is one of the most important

Steve Jobs Personality & Attitudes Drove His Success Case Study

Steve Jobs Personality & Attitudes Drove His Success - Case Study Example From this discussion it is clear that he filtered every distraction from his life, be it even his family so that he remains emotionally stable and is able to produce perfect and elegant products. The last dimension conscientiousness can be pinpointed in him by looking at the several industries he helped upgrading, for instance, music, phones or tablet and personal computing. This wasn’t only about developing product, but making it acceptable for both industries and consumer. An example of this is iTunes where the music industry is being saved from pirated songs being obtained by the consumer and the consumer could upload a collection of their personal music on iPods.   Ã‚  As the paper stresses Steve Job’s stance regarding business was what most of the firm desired. In terms of the five traits of an organizational behavior, Jobs was a perfect symbol. For instance, his self-efficacy was appreciable in form of Apple and Pixar, a name that is common in every household; h e accomplished wonders with both the companies. Regarding his self-monitoring, it can be easily seen that he exploited his own belief that people should be motivated intensely in order to help them break down their resistance and give platform to their imagination and creativity. His self-monitor was deep enough to know that he can accomplish the impossible with rigorous working hours and thinking of something new.  Job’s personality and attitude had a positive effect on the people working with him.

CHILDHOOD OBESITY Research Paper Example | Topics and Well Written Essays - 1250 words

CHILDHOOD OBESITY - Research Paper Example Furthermore, these children have an increased risk of having impaired glucose tolerance, insulin resistance, and may also have diabetes. Obese children are also prone to having breathing problems, and they may further develop asthma. Socially and psychologically, these obese children are likely to have problems such as being discriminated against and having low self-esteem, and these problems are likely to continue way into their adulthood. Obese children have a high likelihood of becoming obese adults, and this is associated with several serious health conditions which include heart disease and some types of cancers. Childhood obesity is a serious medical condition in children who have considerably more weight than is normal for their age and height. It is a very troubling problem because the extra weight often puts the children affected on a path that leads to health problems that one would expect to see only in adults, such as high blood pressure among others. ... w whether their child is obese or not, and it is always best to have a doctor measure the child’s weight in comparison with his or her height to determine whether he or she is in a healthy weight range. Childhood obesity, being a global problem, is increasingly affecting both the developing and the developed countries alike, although at different rates, depending on the economic conditions prevailing in such countries. The problem seems to be aggravated by the transitions in nutritional and physical activity that are currently taking place and are leading to an increase in the use of energy-saving devices, the availability of cheap high-calorie foods, and the limited participation of these children in physical activities both at home and at school. In some cultures in Africa and Asia, for example, the situation is further complicated due to the social and cultural beliefs that consider obesity and excess weight to be signs of wealth and prestige. One of the main reasons why mo re and more children are becoming obese is the fact that many of them spend more time in front of televisions, computers, or video games and, therefore, have less time for physical activity. The busy schedules and lifestyles which the families of today have result in their not having enough time to prepare home-cooked meals full of nutrients, and instead they have the tendency of ordering extremely unhealthy fast food. Bagchi (2010, p.233) states that childhood obesity may lead to some children being miserable about their weight, and these are more prone than those of regular weight to develop unhealthy eating habits and disorders such as anorexia. They are also more prone to depression and are at a great risk of getting involved in the abuse of addictive substances. There are many ways through

N-myristoylation: An Overview

N-myristoylation: An Overview N-myristoylation Protein N-myristoylation is the covalent attachment of myristate, a 14-carbon fatty acid, onto the N-terminal glycine residues of protein substrates. It is transferred co- or post-translationally to a subset of proteins from a thioester form, myristoyl-CoA, catalyzed by N-myristoyl transferases (NMTs). (insert genes expressing nmt1 and nmt2, NMT recognizes a general consensus sequence for myristoylation (Gly-X-X-X-(Ser/Thr/Cys)) containing a N-terminal glycine, 3 other amino acids and a serine, threonine or a cysteine in the fifth position.) While this process is often observed co-translationally on nascent shorter protein substrates, post-translation myristoylation ensues during apoptosis on N-terminal glycine residue exposed after caspase cleavage of protein substrates.1 An increase in proteins hydrophobicity conferred by this modification allows for weak protein-lipid and protein-protein interactions, as well as for membrane targeting and function of proteins involved in signal tr ansduction cascades.2 NMTs served as therapeutic targets owing to their importance for the survival of human pathogens and their association with carcinogenesis.1 To globally profile NMT protein substrates, chemical proteomic approaches have been employed where small tags on fatty acids such as an alkyne (YnMyr) or azide (AzMyr) (Fig. X) were developed to probe myristoylated proteins via metabolic labeling.3,4 This probe was successfully used in a high-confidence profiling of the co-translational myristoylome in human and zebra fish.5 Although YnMyr remains to be the probe of choice owing to its minimal background labeling6, it was demonstrated to label proteins with other known lipid-modifications such as NÃŽÂ µ-myristoyl,7 S-palmitoyl8 and GPI-anchors9-compromising its specificity towards labeling of N-terminal myristoylated proteins. To circumvent the challenge of identifying the true NMT substrates, Tate et al. used an integrated chemical biology approach where selective inhibition of NMT with smal l-molecule inhibitors combined with YnMyr labeling and quantitative proteomics allowed for profiling of more than 30 known and novel protein candidates for N-myristoylation in blood-stage malaria parasite.9 (describe that the presence of inhibitor abolished the labeling of the true substrates, which should not be enriched in control samples) This technology was also applied to globally profile the N-myristoylome of other human pathogens such as in  Leishmania donovani,10 Trypanosoma brucei,11and recently Trypanosoma cruzi.12Theprofiling of a large set of N-myristoylated proteins with diverse cellular functions unravels the significance of this lipid modification in these parasites. Furthermore, this also validates NMT as a viable drug target in attenuating the virulence of these pathogens. Extending the same approach to HeLa cancer cells enabled the identification of more than 100 of both co- and post-translationally modified N-myristoylated proteins, majority of which were identi fied at endogenous levels for the first time.13 Indeed, this robust technique proved to be powerful in discriminating on-target proteins from off-targets in a proteome-wide analysis, resulting in the discovery of novel NMT protein substrates at high confidence. Although promising, the method described where NMT inhibitors were used may not be applicable to more complex systems where cell viability may be compromised, e.g. in the context of viral and bacterial infection. An alternative targeted approach tosimplify data analysis of enriched proteins employs isolating those that bear the N-terminal glycine requirement for N-myristoylation. This enabled the profiling of downregulated host N-myristoylated proteins upon infection with herpes simplex virus (HSV)14, as well as novel fatty-acylated proteins encoded by HSV. This same approach provided a more defined picture of the demyristoylating function of the bacterial effector IpaJ upon host cell invasion of Shigella flexneri, which was determined to contribute to its virulence.15   Palmitoylation Proteins S-palmitoylation is the attachment of a 16-carbon long fatty acid (as palmitate-CoA) to cysteine residues, which was first discovered by radiolabeling of virus-infected cells with [3H]palmitate.16 The formation of the thioester linkage is mediated by a family of protein acyl transferases (PATs) that bear a conserved Asp-His -His-Cys catalytic motif (DHHC-PATs), which can be removed by hydrolysis aided by acyl protein thioesterases (APTs).17 Owing to the reversibility of this modification, S-palmitoylation of proteins was thought to be dynamically regulated ,whereby a subset of proteins are transiently palmitoylated in a certain time point/cellular activity. (insert something) S-palmitoylation has been demonstrated to be an essential mechanism for protein stability, activity, and proper cellular localization.18 Recent advances in identifying palmitoylated proteins revealed not only its key role in regulatory mechanisms but as well as in host invasion and virulence of pathogen s. Large-scale proteomic profiling of S-palmitoylated proteins using metabolic labeling has been heavily dependent on employing the alkyne analogue of palmitic acid, 17-ODYA (Fig. X). This commercially available chemical reporter is suitable for these analyses as it has shown better specificity and has minimal background in labeling proteins that are ought to be acylated by shorter fatty alkyl chains.6 The subsequent click reaction with fluorophore- or biotin-azide then allows for in-gel fluorescence monitoring and biotin-pulldown strategy prior to LC-MS proteomic analysis of labeled proteins, respectively. In these studies, hundreds of palmitoylated proteins were identified with a wide range of functions, highlighting the importance of S-palmitoylation in a plethora of cellular mechanisms and pathways. For instance, the first report on using such strategy applied to mammalian cells identified around 125 candidate S-palmitoylated proteins at high confidence, including G proteins, recept ors and uncharacterized hydrolases.19 Using the same strategy in dendritic immune cells (DC2.4) identified more than 150 predicted S-palmitoylated proteins and revealed that palmitoylation of interferon-induced transmembrane protein 3 (IFITM3)20 and Toll-like receptor 2 (TLR2)21 is essential for their antiviral activity. A more recent study on Cryptococcus neoformans revealed that a single PAT, Pfa4, palmitoylates the fungal proteins required for parasite integrity and virulence-palmitoylating 72 proteins identified in a global-scale approach.22 A more quantitative approach to measure levels of palmitoylated proteins combines metabolic labeling with 17-ODYA and Stable Isotope Labeling with amino acids in Cultured Cells (SILAC). In virus-infected RPE-1 epithelial cells, selective repression was observed for host S-palmitoylated proteins, including interferon signaling regulators and members of the tetraspanin family.14 A novel set of HSV-encoded proteins palmitoylated by the host machinery were selectively and significantly identified, further suggesting that HSV exploits the palmitoylation pathway which contributes to its virulence. As palmitoylation is a reversible process, the dynamic cycling of palmitoylated proteins in mouse T-cell hybridoma cells was investigated using this quantitative approach in combination with a pulse-chase technique.23 Through the use of a serine lipase-inhibitor as the chase, palmitoylated proteins that undergo fast turnovers were distinguished from those that are stably modified. This indicates that a subset of this dynamic palmitoylation event is regulated by serine hydrolases, validating the fundamental regulatory mechanism of depalmitoylation for proteins with rapid turnovers. It is important to note that in this study, only the insoluble protein fractions were analyzed, as the soluble proteins were not amenable to metabolic probe incorporation.19 Given the dynamic nature of palmitoylation, the metabolic labeling strategy would allow labeling of only those that are palmitoylated at the time of probe treatment and were stably modified. An older approach, coined as acyl-biotin exchange (ABE), has the potential to capture the full complement of palmitoylated proteins. In this multistep procedure, the protein lysates are treated with hydroxylamine to selectively cleave the thioester bonds, followed by disulfide capture with thiol-containing biotin analogue, and subsequently enriched through a pulldown technique prior to LC-MS analysis. ABE was first utilized in tandem with semi-quantitative MudPit analysis on profiling the palmitome of Saccharomyces cerivisae.24 The 12 known and 35 new palmitoylated proteins identified presented the first evidence on the diverse specificities of PATs. The ABE method was further employed in profiling the palmitoylome in rat neurons,25 human T cells,26 and recently in poplar tree cells,27 establishi ng its applicability to a wide range of biological systems. Both ABE and metabolic labeling approaches combined with SILAC revealed their large complementarity in profiling S-palmitoylated proteins in Plasmodium falciparum.28 A total of more than 400 palmitoylated proteins were identified where 202 proteins were enriched in both methods. As expected, metabolic labeling identified a lesser number of proteins, reflecting the less complexity in this approach. A pulse-chase labeling using ABE in a quantitative approach with 2-BMP as the parasite PAT inhibitor revealed the identification of a range of stably and dynamically palmitoylated proteins. Indeed, this study demonstrated the importance of palmitoylation in multiple parasite-specific processes, specifically in drug resistance, asexual stage development, host cell invasion, and protein export. Both methods were also employed in investigating the dysregulation of palmitoylation in breast cancer cells by inducing Snail-overexpression- an event correlated with chemoresistance and metastasis.29 Results showed that some proteins were differentially expressed regardless of differential palmitoylation. Thus, Snail-overexpression compromises the dynamic palmitoylation of some proteins that may be involved in pathways that contribute to malignancy. Albeit most proteins are S -palmitoylated in their cysteine residues, others were reported to be O-palmitoylated30 and N-palmitoylated17, which are also labeled by 17-ODYA. To distinguish S-palmitoylated proteins from these other forms in Toxoplasma gondii, a method similar to ABE was employed which also takes advantage of the labilityof thioester bonds to hydrolysis.31 In this approach, the metabolic incorporation of 17-ODYA and enrichment is followed by hydroxylamine cleavage to profile S-palmitoylated proteins. This confirmed 282 hydroxylamine-sensitive proteins from 501 putative palmitoylated proteins enriched from the initial 17-ODYA labeling. This also revealed and validated that palmitoylation of AMA1, a protein essential for host-cell invasion, is not required on invasion but increases microneme secretion. Taken together, these studies presented underscore the utility of large-scale S-palmitome profiling in understanding the biological importance of this lipid modification. Applying these techniques to future palmitome analysis would further discover potentially novel protein functions and cellular mechanisms across different biological systems. Wright, M. H., Heal, W. P., Mann, D. J. Tate, E. W. Protein myristoylation in health and disease. J. Chem. Biol. 3, 19-35 (2010). Farazi, T. A., Waksman, G. Gordon, J. I. The Biology and Enzymology of ProteinN-Myristoylation . J. Biol. Chem. 276 , 39501-39504 (2001). Heal, W. P., Wickramasinghe, S. R., Leatherbarrow, R. J. Tate, E. W. N-Myristoyl transferase-mediated protein labellingin vivo. Org. Biomol. Chem. 6, 2308-2315 (2008). Heal, W. P., Wright, M. H., Thinon, E. Tate, E. W. Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry. Nat. Protoc. 7,105-117 (2012). Broncel, M. et al. Myristoylation profiling in human cells and zebrafish. Data Br. 4, 379-383 (2015). Charron, G. et al. Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters. J. Am. Chem. Soc. 131, 4967-4975 (2009). Liu, Z. et al. Integrative Chemical Biology Approaches for Identification and Characterization of Erasers for Fatty-Acid-Acylated Lysine Residues within Proteins. Angew. Chemie Int. Ed. 54, 1149-1152 (2015). Wilson, J. P., Raghavan, A. S., Yang, Y.-Y., Charron, G. Hang, H. C. Proteomic Analysis of Fatty-acylated Proteins in Mammalian Cells with Chemical Reporters Reveals S-Acylation of Histone H3 Variants. Mol. Cell. Proteomics 10, M110.001198 (2011). Wright, M. H. et al. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem 6, 112-121 (2014). Wright, M. H. et al. Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani. Chem. Biol. 22, 342-354 (2015). Wright, M. H., Paape, D., Price, H. P., Smith, D. F. Tate, E. W. Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. ACS Infect. Dis. 2, 427-441 (2016). Roberts, A. J. Fairlamb, A. H. The N-myristoylome of Trypanosoma cruzi. Sci. Rep. 6,31078 (2016). Thinon, E. et al. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun 5, (2014). Serwa, R. A., Abaitua, F., Krause, E., Tate, E. W. OHare, P. Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics. Chem. Biol. 22, 1008-1017 (2015). Burnaevskiy, N., Peng, T., Reddick, L. E., Hang, H. C. Alto, N. M. Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ. Mol. Cell 58, 110-122 (2015). Schmidt, M. F. G. Schlesinger, M. J. Fatty acid binding to vesicular stomatitis virus glycoprotein: a new type of post-translational modification of the viral glycoprotein. Cell 17, 813-819 (1979). Linder, M. E. Deschenes, R. J. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol 8, 74-84 (2007). Smotrys, J. E. Linder, M. E. Palmitoylation of Intracellular Signaling Proteins: Regulation and Function. Annu. Rev. Biochem. 73, 559-587 (2004). Martin, B. R. Cravatt, B. F. Large-scale profiling of protein palmitoylation in mammalian cells. Nat Meth 6, 135-138 (2009). Yount, J. S. et al. Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nat Chem Biol 6, 610-614 (2010). Chesarino, N. M. et al. Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biol. 12,91 (2014). Santiago-Tirado, F. H., Peng, T., Yang, M., Hang, H. C. Doering, T. L. A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome. PLoS Pathog. 11,e1004908 (2015). Martin, B. R., Wang, C., Adibekian, A., Tully, S. E. Cravatt, B. F. Global profiling of dynamic protein palmitoylation. Nat Meth 9, 84-89 (2012). Roth, A. F. et al. Global Analysis of Protein Palmitoylation in Yeast. Cell 125, 1003- 1013 (2006). Kang, R. et al. Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature 456, 904-909 (2008). Morrison, E. et al. Quantitative analysis of the human T cell palmitome. Sci. Rep. 5, 11598 (2015). Srivastava, V., Weber, J. R., Malm, E., Fouke, B. W. Bulone, V. Proteomic Analysis of a Poplar Cell Suspension Culture Suggests a Major Role of Protein S-Acylation in Diverse Cellular Processes. Front. Plant Sci. 7, 477 (2016). Jones, M. L., Collins, M. O., Goulding, D., Choudhary, J. S. Rayner, J. C. Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis. Cell Host Microbe 12, 246-258 (2012). Hernandez, J. L. et al. Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition. Mol. Biosyst. 12, 1799-1808 (2016). Zou, C. et al. Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O-Palmitoylation to Regulate mRNA Synthesis. J. Biol. Chem. 286 ,28019-28025 (2011). Foe, I. T. et al. Global analysis of palmitoylated proteins in Toxoplasma gondii. Cell Host Microbe 18,501-511 (2015).

Breast Implants :: essays research papers

Friday, 19 May, 2000, 10:13 GMT 11:13 UK Huge rupture rate in breast implants Many of the inplants had ruptured Almost seven out of ten silicone-gel breast implants scanned by researchers had developed a leak. The US Food and Drug Administration (FDA) study could reawaken the debate over the safety of breast implants. Many women claim that leaking silicone-gel has sparked serious illness, including chronic autoimmune disease. The FDA team used MRI scans too look at 344 women with implants. They found that 69% had a least one ruptured implant. And in 21%, the silicone gel contained within the implant had leaked beyond the breast into other parts of the body. In another part of the study, 907 women who had undergone breast enhancement surgery were interviewed. Removed implants Recently published studies have shown that women with silicone gel-filled breast implants do not have a greatly increased risk of some well-defined autoimmune diseases, which were among the serious health concerns surrounding the devices. These include potentially fatal connective tissue diseases such as scleroderma and lupus erythematosus. The new studies do not, however, rule out the possibility that a subset of women with implants may have a small increased risk of these conditions, or that some women might develop other immune-related symptoms that don't conform to "classic" disease descriptions. Nor did the studies address other important safety questions, including implant rupture rates and the incidence of capsular contracture (shrinking of scar tissue around the implant, which can cause painful hardening of the breast or distort its appearance). Answers to these and other questions await the results of new or ongoing studies. Widespread reports of adverse reactions to silicone gel-filled implants and a lack of evidence supporting their safety led the Food and Drug Administration to order the devices off the market in April 1992. They remained available only to women in clinical studies, mostly women seeking breast reconstruction after breast cancer surgery. Saline-filled implants were allowed to remain on the market for all uses. Reasons for New Studies Breast implants had been marketed since the early 1960s--several years before the first medical device law was enacted in 1976, charging FDA with regulation of medical devices. Every year, thousands of American women had implant surgery for augmentation (to enlarge or reshape their breasts) or for reconstruction following mastectomy (removal of the breast) to treat breast cancer. Most of the implants consisted of a rubber silicone envelope filled with silicone gel; about 10 percent were filled with saline (salt water).